La Distillerie de Monaco operates from the principality of Monaco on the French Riviera. This distillery specializes in producing liqueurs, representing one of the few spirits producers based in the Mediterranean microstate.

Monaco's position along the Mediterranean coast provides an ideal climate for citrus cultivation and the production of fruit-based liqueurs. The principality's location has historically made it a crossroads for Mediterranean trade routes, including the movement of exotic fruits and botanicals used in premium spirit production. The warm, sunny climate and proximity to both French and Italian culinary traditions create favorable conditions for artisanal liqueur making.

Based on their current production, La Distillerie de Monaco focuses on fruit liqueurs, with L'Orangerie representing their orange-based offering. This aligns with the Mediterranean tradition of utilizing local citrus fruits, particularly oranges, which thrive in the region's climate and have been used in liqueur production throughout the area for generations.