Tito's Handmade Vodka is produced by Fifth Generation Inc., founded by Tito Beveridge in Austin, Texas in the 1990s. The distillery operates from Texas and produces vodka using traditional pot still methods, which distinguishes it from many larger commercial vodka operations that rely on column distillation.

The vodka is made from yellow corn rather than the wheat or potatoes commonly used by other producers. This corn-based mash bill contributes to a slightly sweeter, rounder flavor profile compared to grain-based vodkas. The spirit undergoes distillation in old-fashioned pot stills and is filtered through activated carbon, following techniques more commonly associated with whiskey production than industrial vodka manufacturing.

Tito's markets itself as a craft vodka and has gained recognition in the American spirits market for its distinctive production methods and Texas origins. The brand represents part of the broader craft spirits movement that emerged in the United States during the late 20th century.